Migraine Trigger: Oxidative Stress
Oxidative Stress is the Universal Migraine Trigger
High levels of oxidative stress are associated with a four-fold increase in migraine risk (study link) and a new study found that nearly all documented migraine triggers are associated with oxidative stress (study link).
The author of the study concluded that migraines may be a defense mechanism against the deadly buildup of oxidative stress.
What is oxidative stress?
Oxidative stress occurs during normal metabolism from free radicals and from just about anything that hurts the body, such as pollution, food allergens, or smoke.
Oxidative stress may lead to chronic inflammation and inflammation can also raise oxidative stress levels (study link). Both play a large role in headache triggers and chronic diseases that are associated with migraines (study link).
The Next Generation Migraine Drug
The next generation migraine drug blocks a peptide that is released during the buildup of oxidative stress and prevents a rapid release of glutamate that is associated with migraines (study link 1, 2, 3).
The Best Way to Block Oxidative Stress
Reducing headache triggers is the best way to reduce oxidative stress. (see the full diet here).
Foods that raise antioxidants levels in the blood will also help to reduce oxidative stress.
However, raising antioxidant levels in the blood is a complex process and just because a supplement or food has antioxidants does not mean that it will automatically raise antioxidants levels in the blood (learn more).
Update: I’ve recently evaluated forty of the conditions associated with migraines. They are all associated with oxidative stress. This will hopefully bring further light to the universal migraine trigger.
Read the article here: Forty Conditions Associated with Migraines and Oxidative Stress.