Forty Conditions Associated with Migraines

This article lists forty conditions that are associated with migraines. All of these conditions are linked to a migraine trigger called oxidative stress.

Forty Conditions Associated with Migraines

This article lists forty conditions that are associated with migraines. All of these conditions are linked to a migraine trigger called oxidative stress (full article).

Don’t panic. The end of this article details a plan to stop oxidative stress and migraines.

Forty Conditions Associated with Migraines:

1.  Hypothyroidism

Hypothyroidism patients are several times more likely to have migraines (study).

Migraineurs are 3.5 times more likely to have hypothyroidism than the general population (study 1, 2).

To learn more about hypothyroidism and migraines, read about why pregnancy often eliminates migraines (full article).

“Hypothyroidism is a state of increased oxidative stress,” according to research done in 2016 (study).

2.  Multiple Sclerosis

Multiple sclerosis (MS) patients are three times more likely to have migraines (study).

MS is an autoimmune disorder in which the body attacks its own nerve cells in the brain and spinal cord.

Oxidative stress increases with the progression of MS (study 1, 2).

3.  Irritable Bowel Syndrome (IBS)

IBS sufferers are 40 to 80 percent more likely to have migraines (study).

A new study found that about half of all migraine patients had IBS. Migraine sufferers under thirty are more than three times as likely to have IBS as the general population (study 1, 2).

Patients with IBS have high levels of oxidative stress and low levels of antioxidants (study 1, 2).

Learn more about the gut in order to discover ways to beat migraines (full article).

4.  Inflammatory Bowel Disease (IBD)

IBD patients are 2.7 times more likely to have migraines (study link).

IBS patients may have short periods of gut inflammation while IBD patients suffer chronic gut inflammation (full article).

Thus, people who suffer from IBD will have higher levels of oxidative stress than people who suffer from IBS (study).

5.  Depression

Depression increases the risk of migraine and vice versa (study).

Suicide is 2.5 times higher in migraine sufferers than in the general population (study 1, 2).

Over 100 studies have shown that depression is associated with oxidative stress (study).

6.  Anxiety

A 2011 study found that patients with generalized anxiety disorder were five times more likely to have migraines than healthy individuals (study).

Up to 75 percent of patients with chronic migraines have anxiety (study).

Oxidative stress is connected with the formation of anxiety (study).

7.  Acne

Children with migraine have seven times the odds of having acne (study).

Acne and migraines are associated with increased levels of inflammation and allergen antibodies (full article).

Oxidative stress is associated with acne and “may be an early event that drives the acne process,” according to research done in 2012 (study).

8.  Sjögren’s Syndrome

Migraine is found in 46 percent of patients with Sjögren’s Syndrome (study).

Sjögren’s Syndrome is an autoimmune condition that affects moisture-producing glands. It’s often found in patients with rheumatoid arthritis (inflammation in the joints).

Excessive levels of oxidative stress are found in people with Sjögren’s Syndrome (study).

9.  Parkinson’s disease

Migraine sufferers have a 64 percent increased risk of developing Parkinson’s disease (study).

Learn more about healthy fats to help you avoid Parkinson’s disease and migraines (full article).

Oxidative stress is associated with Parkinson’s disease and may contribute to the development of Parkinson’s disease (study).

10.  Hypoglycemia (low blood sugar)

A 2015 study found that diabetic patients with hypoglycemic attacks are more likely to have migraines.

The study also found that an increase in years living with type II diabetes will significantly increase migraine risk (study).

Hypoglycemia induces oxidative stress (study).





11.  Restless Legs Syndrome

A 2016 study found that 42.9 percent of patients with restless legs syndrome also had migraine.

Restless legs syndrome causes a strong urge to move one’s legs (video example). This can happen at night and cause sleep disturbances, irritability, depression, and low energy.

Risk factors include low iron levels, Parkinson’s disease, diabetes, and rheumatoid arthritis (study).

Oxidative stress and autonomic dysfunction are associated with restless legs syndrome (study 1, 2, 3).

12.  Autonomic Dysfunction

Autonomic dysfunction is common in migraine sufferers (study).

Migraineurs tend to have norepinephrine levels—a measurement of autonomic function—that are less than 60 percent of those found in healthy people (study link).

Norepinephrine reduces oxidative stress and may reduce migraines (study 1, 2, 3).

Learn how the Wim Hof Method can improve autonomic function and reduce migraines (full article).

13.  Iron-Deficiency Anemia (IDA)

A 2015 study found that 36.2 percent of iron-deficiency anemia (IDA) patients had migraines (study).

A 2016 study found that IDA was more common in menstrual-migraine patients (up to 70 percent of female migraineurs have menstrual migraine) (study).

Iron deficiency increases oxidative stress and iron supplementation can reduce oxidative stress (study).

Eat natural sources of iron or take supplements (amazon).

14.  Lupus

A Harvard Medical School study found that 39 percent of lupus patients also met the criteria for a migraine diagnosis (study).

Lupus is an autoimmune disease in which the immune system attacks healthy tissue (joints, skin, etc.).

Oxidative stress plays a major role in triggering lupus (study).

15.  Carpal Tunnel Syndrome

The odds of having migraines are nearly three times higher for those with carpal tunnel syndrome (study).

Risk factors include obesity, repetitive wrist work, rheumatoid arthritis, and thyroid diseases (study).

Oxidative stress is considered a major cause of carpal tunnel syndrome according to a 2016 study.

16.  Alzheimer’s disease

A study that followed 1700 adults over a period of five years found that a history of migraines more than tripled the risk of developing Alzheimer’s disease (study).

Evidence suggests that oxidative stress promotes the initiation and progression of Alzheimer’s disease (study 1, 2).

Learn more about preventing Alzheimer’s disease and migraines with healthy fats and a reduction of nitrites.

17.  Chronic Fatigue Syndrome

A study from 2013 found that a whopping 82 percent of patients experiencing chronic fatigue syndrome also suffer from migraines (study link).

Oxidative stress levels are elevated in people with chronic fatigue syndrome (study 1, 2).

See cold therapy for migraines.

18.  Asthma

Asthma increased the risk of migraines by 45 percent in a 2016 study of more than 25,000 asthmatic patients (study).

Asthma doubles the risk of chronic migraines (15+ migraine days per month) in episodic migraine patients (under 15 migraine days per month) (study).

Asthma and the severity of asthma are associated with increased oxidative stress (study 1, 2). See butterbur for asthma and migraine prevention.

19.  Stress

Stress is the most common migraine trigger (study link).

Emotional stress is a contributing factor to oxidative stress and to the six leading causes of deaths in the United States: cancer, coronary heart disease, accidental injuries, respiratory disorders, cirrhosis of the liver, and suicide (study 1, 2).

20.  Autism

Anecdotal evidence suggests that autistic patients have an increased prevalence of migraines.

There are also many clinical similarities between autism and migraines (study).

Autism patients show reduced antioxidant levels and increased levels of oxidative stress (study).

21.  Epilepsy

Research shows that about 30 percent of patients with seizures have migraines (study 1, 2).

Oxidative stress is involved in seizures (study). 

22.  Spinal Cord Injury

A spinal cord injury quadruples the odds that a patient will also have migraines (study).

Oxidative stress is common in spinal cord injuries and may be responsible for the loss of coenzyme Q10 (CoQ10) in spinal cord injuries (study).

CoQ10 reduces the effects of spinal cord injuries and migraines (full article).

23.  Allergic Rhinitis (aka: Allergies or Hay Fever)

People with allergic rhinitis are four times as likely to have migraines (study link).

Oxidative stress is elevated in patients with allergic rhinitis (study 1, 2).

24.  Food Allergies

Migraine sufferers are allergic to eight times as many foods as non-migraine sufferers (study link).

Allergens can increase oxidative stress (study). Oxidative stress levels can also influence allergic reactions (study).

25.  Sinus Headache

Ninety percent of sinus headaches are misdiagnosed and actually meet the criteria for migraines. Sixty percent of those misdiagnosed patients are treated with antibiotics that will only increase the risk of migraines (study).

26.  Heart Attack and Stroke

A 2016 study that followed 1700 women over twenty years found that migraine increased the risk of cardiovascular disease by 50 percent, heart attack by 39 percent, and stroke by 62 percent (study).

Male migraineurs have a similar increased risk of heart attack, according to Harvard research (study).

A recent study found that female migraineurs have more than double the risk of suffering a stroke (WebMD).

Cardiovascular risk factors increase oxidative stress (study).

27.  Traumatic Brain Injury (TBI)

Migraines are very common after a TBI (study).

A 2014 study found that about 44 percent of patients had migraines after mild TBIs (study).

A study on high school football players found that 50 percent of players with multiple concussions had migraines (American Headache Society).

Numerous oxidative stress markers are increased and eight different antioxidant markers are decreased after a TBI (study).

Animal TBI studies show that a switch (Nrf2) that activates antioxidants reduces oxidative stress and may protect people from brain injury (study).

Omega-3 fats also activate the switch that increases antioxidants and may prevent migraines (full article).

28.  Osteoporosis

A study of more than 80,000 patients found that the risk of migraine is tripled in osteoporosis patients (study).

Oxidative stress levels are increased in people with osteoporosis and have been proposed as an underlying mechanism in bone destruction (study).

Don’t drink milk, it’s a migraine trigger (full article). Milk consumption is also associated with more broken bones (study).

29.  Obesity

Obesity increases migraine risk by 81 percent (study link).

“Obesity is characterized by permanently increased oxidative stress,” according to 2014 research from Italy (study).

30.  Eating Disorders

Women who had a history of an eating disorder were twice as likely to have migraines in a study conducted in Finland (study).

Oxidative stress is produced in anorexic patients (study).

31.  Temporomandibular Joint Dysfunction (TMD)

A massive 55.3 percent of TMD patients also had migraines in a 2010 study conducted in Brazil (study).

TMD is an umbrella term for “pain in the jaw.” TMD may trigger migraines by inflaming the trigeminal nerve (facial nerve).

Oxidative stress is closely associated with TMD and seems to influence the development of TMD (study 1, 2).

32.  Bipolar Disorder

A study of over 36,000 Canadians found that bipolar disorder more than doubled the risk of migraines (study).

A small study from Norway found that 77 percent of bipolar II patients also had migraines (study).

A collection of 27 studies found that bipolar patients have increased levels of oxidative stress and nitric oxide (study).

Read more about the migraine trigger nitric oxide here.

33.  Cyclic Vomiting Syndrome (CVS)

CVS develops in childhood and often transitions into migraines (study 1, 2). Sufferers may vomit twelve times per hour and an episode may last from a few hours to over three weeks (study).

One study found that a history of migraines in the family was present in 72 percent of CVS patients (study).

Frequent vomiting leads to inflammation in the gut and gut inflammation is associated with increased levels of oxidative stress (study 1, 2, 3).

Oxidative stress is also associated with vomiting during pregnancy (study).

34.  Post-Traumatic Stress Disorder

Migraineurs are about five times more likely than non-migraine sufferers to have PTSD at some point in their lives.

Male migraineurs are roughly three times as likely to have PTSD than female migraineurs (study).

Although no studies have measured oxidative stress in PTSD, a growing body of evidence suggests PTSD increases oxidative stress (study).

35.  Abuse

A history of physical abuse, sexual abuse, child abuse, or parental domestic violence greatly increases the risk of developing migraines (study 1, 2, 3).

Animals exposed to stress (essentially abuse) exhibit raised levels of oxidative stress (study).

Oxidative stress levels are raised in chronically stressed caregivers, clinically depressed patients, and even college students before examinations (study).

36.  Idiopathic Intracranial Hypertension (IIH)

Idiopathic Intracranial Hypertension translates into the unknown cause (idiopathic) of pressure (hypertension) within the skull (intracranial).

The majority of chronic migraineurs that are unresponsive to medications have increased intracranial pressure. Pressure and migraine disability can be temporarily relieved by a lumbar puncture (study).

Obesity is common in IIH patients and obesity predicts intracranial pressure in migraineurs (study).

Obesity is associated with oxidative stress and IIH has been associated with increased levels of oxidative stress in some patients (study).

37.  Celiac Disease

A 2013 Columbia University study found that celiac patients had triple the odds of having migraines.

Gluten sensitive patients had 9.5 times the odds of having migraines as the control group (study).

Oxidative stress is released as a result of the toxic response to gluten in celiac patients (study).

Read more about the migraine trigger wheat here.

38.  Benign Paroxysmal Positional Vertigo (BPPV)

BPPV is a disorder stemming from the inner ear. It’s the most common cause of vertigo.

A 2015 study from Taiwan showed that migraine sufferers have double the risk of developing BPPV (study).

Patients with BPPV have elevated levels of oxidative stress (study).

A 2016 study suggested that oxidative stress contributes to the development of BPPV (study).

39.  Insomnia

A Korean headache-sleep study of over 2000 participants found that insomnia was about five times more likely in migraine patients than in non-headache sufferers (study).

Patients with insomnia have increased levels of oxidative stress (study).

To avoid insomnia, read about blue light, melatonin, and migraines.

40.  Sexual Dysfunction

A 2016 study of 5015 migraineurs found that migraine more than doubled the risk of erectile dysfunction (study 1, 2).

About 68 percent of female migraineurs also suffer from sexual dysfunction (most notably from a lack of desire and arousal) (study).

Oxidative stress accumulates in the erectile tissue (clitoris or penis tissue) of erectile dysfunction patients and plays a role in the progression of erectile dysfunction (study 1, 2).


41.  Fibromyalgia
A 2015 study of over 1700 fibromyalgia patients found that 55.8% had migraines (study).

Oxidative stress and inflammation are common in the skin of fibromyalgia patients (study). Fibromyalgia is characterized by widespread muscle pain and fatigue.

42. Attention Deficit Hyperactivity Disorder (ADHD)

Adults with ADHD are significantly more likely to have a migraine diagnosis. Men with ADHD have a doubled risk of migraine (study).

A study published in 2016 found that oxidative stress levels are significantly higher in children with ADHD (study).

Why Oxidative Stress?

A 2016 study found that nearly all migraine triggers are associated with oxidative stress (full article). The conditions associated with migraine further establish the role of oxidative stress in migraines.

Many of the studies above found that migraines increased the likelihood of a disease.

It’s evident that migraines are the body’s defense mechanism against the deadly buildup of oxidative stress.

High levels of oxidative stress do in fact increase the odds of having migraines four-fold (study).

Other studies discussed showed that migraines developed after a disease or became significantly worse as a disease took hold.

This evidence suggests that diseases worsened by oxidative stress will increase the likelihood of migraines.

Genetics is Only One Part of the Equation

A genetic predisposition to migraines, obesity, cardiovascular disease, or anything else is not a death sentence. It’s far from it.

Genetics make obesity more likely, but that doesn’t mean you can’t avoid obesity by reducing fattening foods that cause oxidative stress.

Migraines are more difficult to avoid because they are a defensive mechanism for all forms of oxidative stress. Glutamate, nitrites, dehydration, blue light, alcohol, pollution, and food allergens are just of few of the common migraine triggers.

The good news is that migraines are part of a headache threshold that is based on total levels of oxidative stress.

You may not be able to avoid certain allergens in the air or stressful situations, but that’s ok. You can reduce total levels of oxidative stress in a multiple of other ways.

Research shows that dietary changes are the most successful way to improve the headache threshold and completely eliminate migraines—in as little as three days (full article). Food eliminations can even make triggers such as noise or stress nonexistent.

The 3-Day Migraine Diet is based on successful studies that have eliminated migraines in addition to reducing oxidative stress.

The 3-Day Headache “Cure” book and guide are also great resources for finding and eliminating the oxidative stress caused by the top migraine triggers.

Author: Jeremy Orozco

Jeremy Orozco is a former firefighter turned migraine expert, author, and co-founder of He's the author of Hemp for Migraine and The 3-Day Headache "Cure". You can find Jeremy here at and on Facebook. (See Jeremy's full bio.) // is dedicated to eliminating headaches and migraines. Forever. Share this post to help headache and migraine sufferers.

This is not medical advice, diagnosis, or treatment. Read the disclaimer.

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